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The appropriate dosing regimen for a drug depends on exposure-effect relationships (see dose determination and dosibundling study) and is based on in vitro, in vivo and clinical evidence. Depending on the class of drugs and its pharmacokinetic and pharmacodynamic properties, different dosage regimens may be optimal, including once a day (omne in die, OD), twice a day (up to the, BID) or three times a day (ter in die, TID). Considerations on the dosage of drugs in critically ill patients receiving continuous renal replacement therapy (Pharmacy, 2020) It depends on the dosage regimen: the importance of early intervention and rapid achievement of the pharmacokinetic/pharmacodynamic target (antimicrobials and chemotherapy, 2012) b.i.d. (prescription): Prescription, b.i.d. means two (twice) a day. It is an abbreviation of «bis in die», which in Latin means twice a day. The abbreviation b.i.d. is sometimes written without a period, either in lowercase as «BID» or in uppercase as «BID». Regardless of how it is written, it is one of many sacred abbreviations of Latin terms traditionally used in prescriptions to indicate how often medications should be taken. IDB: up to, twice a day; TID: ter in the: three times a day.